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Stasys Medical receives NIH CATALYZE R33 grant

In conjunction with Vanderbilt University Medical Center, this follow-on grant allows for a 1000 patient study at the renowned VUMC Emergency Medical Center. This large multi-year study focuses on using ATLAS outputs to predict bleeding, blood product transfusion requirements, and patient outcomes, as well as developing an AI powered model for improving detection of platelet dysfunction. Principal investigators include Stasys Director of Research & Development Dr. Lucas Ting, and VUMC Professor Sean Collins, M.D. (Executive Vice Chair, Emergency Medicine).

Stasys Medical receives NIH CATALYZE R61 grant

Grant Title: Rapid platelet dysfunction detection in whole blood samples using machine learning powered micro-clot imaging.

The grant facilitates Stasys Medical to further develop and improve machine vision and machine learning driven analysis of images captured by the ATLAS. It is led by Stasys Director of Research & Development Dr. Lucas Ting.

Stasys Medical is excited to announce the publication of "Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk" in Nature Communications. It is authored by Stasys team members Lucas Ting, PhD., Nathan Sniadecki PhD., and Nathan White MD

Abstract: Platelets contract forcefully after their activation, contributing to the strength and stability of platelet aggregates and fibrin clots during blood coagulation. Viscoelastic approaches can be used to assess platelet-induced clot strengthening, but they require thrombin and fibrin generation and are unable to measure platelet forces directly. Here, we report a rapid, microfluidic approach for measuring the contractile force of platelet aggregates for the detection of platelet dysfunction. We find that platelet forces are significantly reduced when blood samples are treated with inhibitors of myosin, GPIb-IX-V, integrin αIIbβ3, P2Y12, or thromboxane generation. Clinically, we find that platelet forces are measurably lower in cardiology patients taking aspirin. We also find that measuring platelet forces can identify Emergency Department trauma patients who subsequently require blood transfusions. Together, these findings indicate that microfluidic quantification of platelet forces may be a rapid and useful approach for monitoring both antiplatelet therapy and traumatic bleeding risk.

Read the paper
Stasys Medical receives NSF SBIR Phase II grant for development of a device to rapidly identify the source of uncontrolled bleeding in major trauma

SEATTLE, Wash. – March, 2015 – Stasys Medical Corporation has received a National Science Foundation Small Business Innovation Research Phase IIb grant (NSF SBIR PIIb), and a National Institute of health Small Business Innovation Research grant (NIH SBIR PI) totaling $725K. The company will use these grants to conduct product development and research to understand the ways that Stasys’ technology can be utilized to help manage bleeding and coagulation in surgical, ER, and personalized medicine applications. This is the latest grant award in addition to receiving a NSF SBIR PII award, and investment led by Table10 group bringing the recent investment into Stasys to $2.1M.

Supporting Grant Information